After infection, compared with KOMV mice, KOMV-MEM mice exhibited the highest mortality, the most significant weight loss, and markedly elevated serum pro-inflammatory cytokine levels (TNF-α, IL-6, and IL-1β) (P < 0.01); In contrast, compared to KOMV-MEM mice, KOMV-MEM-CA mice exhibited lower mortality and a reduced trend in weight loss, along with a significant decrease in serum pro-inflammatory cytokine levels (P < 0.01). The gene discussed is IL6; the disease is infection.