This study underscores the value of WES in uncovering genetic variants associated with epilepsy, focusing on two novel findings: AP3B2 (NM_001278512.2: c.3190G > A; p.Val1064Ile) and PIGB (NM_004855.5: c.1664G > C; p.Ter555Serext∗54). Here, PIGB is linked to epilepsy.