We evaluated the therapeutic synergism between intratumoral injection of oxaliplatin (OxPt) and the imidazoquinoline TLR7/8 agonist 1-(4-(aminomethyl)benzyl)-2-butyl-1H-imidazo[4,5-c]quinolin-4-amine (IMDQ) in a syngeneic CT26 mouse tumor model. The gene discussed is TLR7; the disease is neoplasm.