In OLP, following an increase in the local and systemic release of IL-1 and TNF-α, the keratinocytes, macrophages, T-cells, endothelial cells, and fibroblasts release significant amounts of IL-8, which eventually results in infiltration of T-cells, including cytotoxic T-cells, at the site of OLP lesions (16). This evidence concerns the gene TNF and oral lichen planus.