Notably, 9 additional cancer driver genes (ABL2, CREBBP, ERBB4, FAM135B, HERC2, NIPBL, RANBP2, RNF213, and WNK2) were associated with unfavorable prognosis in LCNEC, cSCLC-LCNEC, and SCLC, respectively (Fig. S6A). Here, CREBBP is linked to large cell neuroendocrine carcinoma.