Patients with CKD may develop gynecomastia due to CKD-associated hormonal dysfunction, including secondary hypogonadism resulting from suppression of testosterone production, elevated follicle-stimulating hormone (FSH) and luteinizing hormone (LH), and/or hyperprolactinemia caused by decreased renal clearance [1, 4, 5]. The gene discussed is PLOD1; the disease is hypogonadism.