For instance, hub genes such as VSNL1, GABRA4, GABRB1, ACTG2, SCN1A, NFASC, AQP4, MYH6, COL1A1, and CSRP2 have been identified primarily clustering in extracellular matrix remodeling and sarcomere dysfunction in severe viral myocarditis cases. The gene discussed is ACTG2; the disease is viral myocarditis.