AQP4 and viral myocarditis: For instance, hub genes such as VSNL1, GABRA4, GABRB1, ACTG2, SCN1A, NFASC, AQP4, MYH6, COL1A1, and CSRP2 have been identified primarily clustering in extracellular matrix remodeling and sarcomere dysfunction in severe viral myocarditis cases.