Minor external stimuli can lead to adverse events, which was first proposed by Fried et al. in 2001.16 Frailty is correlated with multiple adverse consequences in IBD patients, such as elevated mortality, heightened risk of infection, and increased CRP levels.10,11,21 However, frailty and inflammation are dynamically interrelated, and interventions aimed at the factors influencing frailty can ameliorate the progression of inflammation and thereby control the recurrence of the disease.10 Thus, the early identification of factors influencing frailty is particularly crucial. The gene discussed is CRP; the disease is inflammatory bowel disease.