At the molecular level, the inflammatory environment in HT can activate various signaling pathways, including Nuclear Factor kappa-light-chain-enhancer of activated B cells (NF-κB) and the Signal Transducers and Activators of Transcription (STAT) family, which play crucial roles in tumor cell proliferation, survival, and immune evasion (49, 50). The gene discussed is NFKB1; the disease is neoplasm.