Studies show that PDPN expression in CAFs predicts poor prognosis in various cancers, including lung, breast, and pancreatic cancer, and is linked to increased tumor progression Invasive breast cancer with PDPN-positive CAFs tends to have a more aggressive pathological status, characterized by higher lesion-to-muscle ratios and rim enhancement in imaging. This evidence concerns the gene PDPN and familial pancreatic carcinoma.