They perform functions such as: (i) releasing soluble factors, including growth factors like VEGF, PDGF, FGF, and cytokines, which stimulate tumor cell proliferation; (ii) altering the tumor microenvironment by remodeling the extracellular matrix or changing its pH; and (iii) promoting angiogenesis, which improves tumor metabolism, supports cell proliferation, and facilitates metastasis by enabling the release of circulating tumor cells. Here, VEGFA is linked to neoplasm.