GSTM1 and Schnyder corneal dystrophy: In terms of detection capability, the conventional sickling test and the solubility test can detect the presence of HbS, but not of β-thalassemia or HbA; the lateral flow assays (HemoTypeSC, Sickle SCAN) can detect phenotypes for normal, SCT and SCD (but not β-thalassemia); the Gazelle and the automated sickling test can detect phenotypes for normal, SCD due to HbSS and HbS/β-thalassemia, SCT, and β-thalassemia trait; while Hb HPLC can detect the previously mentioned phenotypes as well as other Hb variants that lead to SCD when coinherited with HbS, e.g. HbDPunjab (Fig. 2a).