IL1R1 and colitis: Mitigation of inflammation by the IL-1R1 inhibitor anakinra can down-regulate Ptx3, repair the gut barrier, and slow down TedCH. The study demonstrates that PTX3/IL-1β signaling-associated clonal hematopoiesis plays important roles in the gut-bone marrow axis and related colitis and leukemia (Fig. 1M).