In BLCA (HR = 1.6, p = 0.0028), COAD (HR = 1.8, p = 0.015), kidney renal clear cell carcinoma (KIRC) (HR = 1.5, p = 0.015), lung squamous cell carcinoma (LUSC) (HR = 1.4, p = 0.022), and STAD (HR = 1.4, p = 0.036), OS was lower in high-expression group of CHRDL1, while in LUAD (HR = 0.66, p = 0.0062) and skin cutaneous melanoma (SKCM) (HR = 0.71, p = 0.012), OS was lower in low-expression group of CHRDL1. This evidence concerns the gene CHRDL1 and squamous cell lung carcinoma.