Among them, expression of CHRDL1 was a risk factor for 8 types of cancers, including STAD, BLCA, acute myeloid leukemia (LAML), kidney pancreatic cancer (KIPAN), COAD-rectum adenocarcinoma (COAD-READ), lung squamous cell carcinoma (LUSC), KIRC, and COAD (HR > 1, p < 0.05), while it was a protective factor for 4 types of cancers, namely LUAD, SKCM, mesothelioma (MESO), and SKCM-metastatic (SKCM-M) (HR < 1, p < 0.05) (Figure 3B). Here, CHRDL1 is linked to rectum adenocarcinoma.