In this study, we emphasize the significance of the in vitro findings by analyzing the effects of DXC on the retinal activity and expression of MMP-2 in a mouse model of OIR which reproduces neovascular disorders such as retinopathy of prematurity and proliferative diabetic retinopathy (Smith et al., 1994). This evidence concerns the gene MMP2 and proliferative diabetic retinopathy.