TFRC and acute myeloid leukemia: Following LV-TFR1 virus transfection for 72 h, we observed a significant increase in both the mRNA (MV4-11: control vs LV-TFR,P < 0.01; MOLM-13: control-LV vs LV-TFR1,P < 0.01) and protein levels of TFR1 in AML cells (Figure 6A).