The results confirmed that ferric citrate significantly reduced the cytotoxic effect of cytarabine on wild-type AML cells (MV4-11/MOLM-13) (MV4-11: 0.25 μM cytarabine vs 0.25 μM cytarabine + 500 μM Fe,P < 0.05; MOLM-13: 0.25 μM cytarabine vs 0.25 μM cytarabine + 500 μM Fe,P < 0.05), whereas no significant effect was observed in mutant TP53 AML cells (THP-1/SKM1) (Figure 4C,D). Here, TP53 is linked to acute myeloid leukemia.