The present study provides evidence that DHM can attenuate the increase of creatinine, BUN, KIM-1, NGAL, renal pathological damage, oxidative stress, mitochondrial damage, mitochondrial-mediated apoptosis, and epithelial cell injury in cisplatin (CP)-induced AKI, which may be involved in EGFR/HSP27/STAT3 pathway. This evidence concerns the gene EGFR and acute kidney injury.