The results demonstrated that DCP (OR 12.15, 95% CI 8.96–16.48; p < 0.001), CA125 (OR 0.74, 95% CI 0.54–0.99; p < 0.05), gender (OR 4.17, 95% CI 3.02–5.75; p < 0.001), age (OR 0.47, 95% CI 0.36–0.62; p < 0.001), ALT (OR 0.43, 95% CI 0.31–0.60; p < 0.001), TP (OR 0.35, 95% CI 0.25–0.48; p < 0.001), and ALB (OR 2.53, 95% CI 1.85–3.45; p < 0.001) were recognized as independent factors for poor prognosis of HCC patients. The gene discussed is ACE; the disease is hepatocellular carcinoma.