When ALT, AST, TBil, DBil, and ALB were combined as a stratification factor, the specificity of DCP in HCC diagnosis reached up to 93.92% with sensitivity at 69.09% in the cohort of normal liver function versus 70.39% with sensitivity at 86.30% in the cohort of abnormal liver function. The gene discussed is GPT; the disease is hepatocellular carcinoma.