Results show that IL1RAP is most highly expressed by t(6;9), t(8;21) and NKt-AML (n = 12) both at the protein (surface proteomics, Leucegene AML surfaceome cohort (n = 100), Fig. 3A) and transcript levels (transcriptome, Leucegene RNA-sequencing cohort (n = 691), Fig. 3B, t(8;21) Fig. S3 A). Here, IL1RAP is linked to acute myeloid leukemia.