Elevated expression of IL1RAP has been documented in many type of cancer including solid tumors (pancreatic ductal adenocarcinoma, Ewing sarcoma, gliomas, triple negative breast cancer, non-small cell lung cancer, stomach adenocarcinoma, or cervical cancer), and hematological malignancies (CML and AML) [50, 51]. Here, IL1RAP is linked to chronic myelogenous leukemia, BCR-ABL1 positive.