PLAT and age-related macular degeneration: The TIGER trial is a pan-European randomised controlled surgical trial (RCT) aiming to test the hypothesis that vitrectomy, subretinal tissue plasminogen activator (TPA), intravitreal sulfahexafluoride (SF6) gas tamponade, and aflibercept are superior to aflibercept monotherapy, with respect to Early Treatment of Diabetic Retinopathy Study (ETDRS) best-corrected visual acuity (BCVA) as the primary outcome, in the management of submacular haemorrhage (SMH) secondary to exudative age-related macular degeneration (AMD) at 12 months.