Mimicking stress with isoprenaline, an agonist of the β2-adrenergic receptor, upregulates Vegfr2 in HUVEC and MGC803 cells from a tumor xenograft in BALB/c mice, an effect that was dependent of plexinA1/VEGFR2-JAK2-STAT3 activation [10, 11]. This evidence concerns the gene KDR and neoplasm.