Of these, 7 genes (IRS4, PLS3, SCN3 A, NUDT10, SLC30 A10, SLC10 A4 and ARHGEF10) were upregulated and 31 genes including DHRS9, TKDP4, TKDP1, CDKN1 C, SRARP and TBX2, were downregulated in CM compared to CF as well as in HM compared to HF embryos (Table 5). The gene discussed is PLS3; the disease is cystic fibrosis.