IRS4 and cystic fibrosis: Among the DEGs, the expression levels of NTSR1, NPSR1, ITGB6, SEMA5 A, IRS4, ISG15, DIRAS2 and PIWIL2 were increased, whereas the expression levels of MAGEB16, CPO and FOSB were decreased by at least by 4 folds in CM compared to CF (Fig. 2).