CCDC146 and obesity due to melanocortin 4 receptor deficiency: Novel reproductive hormone variants associated with testosterone in women include those near LAMTOR4 (rs17250196: MAF of 5.13%, β = −0.131 (0.0067), P = 4.02 × 10−86), associated with hyperthyroidism23 and age at menarche and menopause43, and obesity-associated CCDC146 (rs138240474: MAF of 0.63%, β = −0.116 (0.0207), P = 2.03 × 10−8)44, which is expressed in the fallopian tubes and endometrium45.