We analyzed the 450k UKBB exome-sequencing dataset to characterize the association between rare coding variation (MAF <1%) and binary traits with >100 cases (F-ALL (3,746 cases, 260,413 controls), F-EXCL (3,012 cases, 261,147 controls) and M-ALL (650 cases, 222,393 controls)), and quantitative traits with >10,000 participants (FSH-F (n = 20,800), LH-F (n = 16,391), estradiol-F (n = 54,609) and testosterone (nfemale = 197,038, nmale = 197,340)) (Fig. 1). This evidence concerns the gene BRD2 and acute lymphoblastic leukemia.