TRHR and ovarian dysfunction: While we found modest genetic correlation between female infertility and age at first sexual intercourse (−18.8%), indicating that the latter captures some shared biology with fertility, our meta-analyses prioritize novel genes with putative roles in male and female gonads, such as TRHR for ovarian insufficiency and ENO4 for sperm motility, those responsible for development of the endocrine system, such as UMODL1, and pharmacogenetic interactions, such as the association of SLC47A2 with female infertility, potentially mediated by response to metformin.