CD248, which has been recently linked with insulin metabolism [46], NAD(P)H quinone dehydrogenase 1 (NQO1) and tenomodulin (TNMD) were downregulated following LIWL, and expression was reduced in SAT of individuals with or without obesity of the LATC and OA cohorts. The gene discussed is CD248; the disease is obesity due to melanocortin 4 receptor deficiency.