The genes glycerol‐3‐phosphate dehydrogenase 1 like (GPD1L), gasdermin B (GSDMB) and molybdenum cofactor synthesis 1 (MOCS1) were upregulated after LIWL, and expression was increased in SAT of individuals with or without obesity of the LATC and OA cohorts. Here, MOCS1 is linked to obesity due to melanocortin 4 receptor deficiency.