CD248, which has been recently linked with insulin metabolism [46], NAD(P)H quinone dehydrogenase 1 (NQO1) and tenomodulin (TNMD) were downregulated following LIWL, and their expression was also reduced in SAT of individuals with or without obesity of the LATC and OA cohort. Here, INS is linked to obesity due to melanocortin 4 receptor deficiency.