The DEG analysis of SAT in the LIWL cohort and the two other cohorts revealed 39.6% overlap of the DEGs in the LIWL cohort with the LATC cohort, and all identified DEGs in the OA cohort overlapped with the LIWL and LATC cohort (Supporting Information Figure 4): The genes glycerol‐3‐phosphate dehydrogenase 1 like (GPD1L), gasdermin B (GSDMB) and molybdenum cofactor synthesis 1 (MOCS1) were upregulated after LIWL, and their expression was also increased in SAT of individuals with or without obesity of the LATC and OA cohort. Here, GSDMB is linked to obesity due to melanocortin 4 receptor deficiency.