The genes glycerol‐3‐phosphate dehydrogenase 1 like (GPD1L), gasdermin B (GSDMB) and molybdenum cofactor synthesis 1 (MOCS1) were upregulated after LIWL, and expression was increased in SAT of individuals with or without obesity of the LATC and OA cohorts. The gene discussed is GPD1L; the disease is obesity due to melanocortin 4 receptor deficiency.