CBD also interacts with the endocannabinoid system, with emerging evidence suggesting that this system is altered in human ALS (i.e. increased spinal cord cannabinoid receptor 2 density) as well as the SOD1G93 A mouse model (abnormal striatal cannabinoid receptor 1 sensitivity) (Rossi et al. 2010; Yiangou et al. 2006). Here, CNR1 is linked to amyotrophic lateral sclerosis.