This study aims to explore the potential roles of Laminin and BCL-2 in the etiology of HD and HAEC by examining their expression levels.<h4>Methods</h4>Tissues from 20 Rectosigmoid Hirschsprung patients (10 with and 10 without postoperative HAEC) and 10 controls were analyzed retrospectively. The gene discussed is LAMB2; the disease is Huntington disease.