To investigate the upstream signaling that potentially modulates MGAT1 in the context of tumor invasion, we conducted Spearman’s rank correlation analysis using proteomic datasets from the PDC000408 cohort33 and found a tight correlation between elevated expression of MGAT1 and up-regulation of THBS1 and THBS2 signaling pathways (Fig. 5l). This evidence concerns the gene THBS1 and neoplasm.