SPI1 and osteoarthritis: Chondrocyte senescence and the senescence-associated secretory phenotype are the key pathological characteristics of osteoarthritis.27 Abnormal mechanical stress significantly contributes to chondrocyte senescence.28 Despite the well-established critical role of SPI1 in immune cell-related tumors,9 the specific regulatory functions of SPI1 in the aging-related mechanisms underlying OA remain unclear.