For example, decreased levels of the UPRmt components LONP1 and ClpP have been observed in senescent lung fibroblasts.36,37 Downregulation of HSP60 leads to elevated ROS levels and activation of the AMPK‒mTOR pathway, thereby inhibiting glioblastoma cell proliferation.38 Our findings revealed lower expression levels of the UPRmt-related genes HSP60, LONP1, ClpP, and ATF5 in chondrocytes under abnormal mechanical stress and during aging. This evidence concerns the gene CLPP and glioblastoma.