ABCD3 and colorectal carcinoma: Unexpectedly, we observed a significant decrease of PMP70 puncta in HCT116 and HCT8 but an opposite increase of it in LOHP-resistant cells upon LOHP treatment (Fig. 2A, B), suggesting peroxisomal abundance increase might be critical to the CRC cells in responding to the LOHP-caused stress.