Additionally, EZH2 (Enhancer Of Zeste 2 Polycomb Repressive Complex 2 Subunit), a methyl transferase controlling the epigenetic silencing of specific genes and/or microRNAs by trimethylating Lys27 on histone H3 [9], has been identified as the most deregulated histone modifier in adrenocortical cancer. Here, EZH2 is linked to adrenal cortex carcinoma.