Vimentin’s interaction with mitogen-activated protein kinase kinase 4 (MAP2K4) propagates the effect of MAP2K4 on promoting breast cancer cell proliferation, migration, and invasion by activating the PI3K/AKT pathway, the downstream proteins such as c-JUN, the G1/S cell cycle, and the EMT [98]. Here, MAP2K4 is linked to breast carcinoma.