SST and neuropathic pain: Compared to the Gan et al. study, which used sophisticated optogenetic and chemogenetic tools to dissect projection-specific circuits, the present study takes a complementary but distinct approach, demonstrating that eMCS can increases the activity of inhibitory interneurons in S1, and particularly activating S1 SST+ interneurons and suppressing LV-PN hyperactivity associated with neuropathic pain.