Studies predicting the risk of readmission in HF patients have been based on clinical parameters such as brain natriuretic peptide or N-terminal brain natriuretic peptide levels, renal insufficiency, comorbidities, and previous hospitalization history.[4] However, in terms of “risk prediction,” classic cardiovascular risk markers such as soluble CD40 ligand (sCD40L), have rarely been explored. This evidence concerns the gene CD40LG and hydrops fetalis.