In animal models, previous studies have shown that CD40L promotes platelet aggregation, monocyte recruitment, and exosmosis by promoting the formation of ultra-large von Willebrand factor multipliers, leading to atherosclerosis.[15] In a myocardial infarction model, recombinant sCD40L can specifically bind alphaIIbbeta3 and activated platelets, inducing platelet diffusion.[16] Some studies have explored the relationship between cardiovascular disease and sCD40L levels. This evidence concerns the gene VWF and atherosclerosis.