White cord syndrome (WCS), or spinal cord ischemia–reperfusion injury, occurs when sudden reperfusion post-decompression triggers oxygen-free radical overproduction and inflammatory cytokine surge (TNF-α, IL-1β), disrupting the blood–spinal cord barrier.[17] The incidence and severity of WCS are closely related to the duration of ischemia, the extent of ischemic tissue, and the oxygen demand of the affected tissue. Here, IL1B is linked to ischemia.