Cancer stem cells (CSCs), a subset of tumor cells with pluripotent tumorigenic potential, metastatic dissemination, drug resistance, and cancer recurrence, are regulated by a core set of TFs that govern stemness‐specific gene expression profiles, including the key stem cell regulators octamer‐binding transcription factor 4 (OCT4), SRY‐Box transcription factor 2 (SOX2), and NANOG [59]. This evidence concerns the gene POU5F1 and cancer.