Using RT‐qPCR and Western blot (WB), we confirmed the expression of the key gene CXCL14 in the cytokine–cytokine receptor interaction pathway, and observed that the expression of CXCL14 was significantly upregulated in mice after oral administration of DI, regardless of whether E. coli was used to induce endometritis (Figure 7E, Figure S8A,B, Supporting Information). The gene discussed is CXCL14; the disease is endometritis.