The same research group also demonstrated that LLCm1 cells responded to transient acidification with an increase in Trpm5 mRNA, but this result was not confirmed in LLCm1 acidic pHe-adapted (LLCm1A) cells, suggesting that chronic exposure to the acidification of the tumor microenvironment promotes an adaptation both in genotype and phenotype of cells [131]. The gene discussed is TRPM5; the disease is neoplasm.