Furthermore, GJB3 knockdown reduced lung cancer cell proliferation and migration, inhibited the PI3K/AKT pathway in lung adenocarcinoma (LUAD), pancreatic adenocarcinoma (PAAD), and mesothelioma (MESO), and altered pathway activity in H2030, PANC1, and H2452 cancer cell lines [166]. This evidence concerns the gene GJB3 and cancer.