An in vitro study in the 4T1 cell line suggested that tumors may induce neutrophil extracellular traps (NETs) by the release of spermidine via Panx1: Panx1-deficient 4T1 cells showed a reduction in tumor volume to control cells in vivo when subcutaneously transplanted into mice, whereas the inhibition of spermidine synthesis suppressed tumor growth in the mouse transplant model [152]. This evidence concerns the gene PANX1 and neoplasm.