While STs exhibit a distinct mutational landscape compared to cutaneous melanomas, the MelArray panel reliably detects key alterations associated with melanomas, particularly those critical for evaluating the lesion’s biological behavior (e.g., TERT-p, ARID2, TP53, or CDKN2A) [1,8,16]. The gene discussed is CDKN2A; the disease is cutaneous melanoma.