Tumor cells and stromal cells secrete a variety of chemokines and cytokines, including cysteine X cysteine ligands such as CXCL1, CXCL2, CXCL5, and CXCL8 (IL-8), that attract neutrophils to the tumor site (Figure 1A) [14]. Here, CXCL1 is linked to neoplasm.