CXCR2 and neoplasm: Neutrophils contribute to the establishment of pre-metastatic niches by secreting chemokines such as ARG1, CXCL1, CXCL2, CXCL10, CCL2, CXCR2, and vascular endothelial growth factor A (VEGFA), which attract tumor cells to metastatic sites (Figure 1E) [47,49].