Arginase 1 is a key marker for M2 polarization in cancers, significantly contributing to the immunosuppressive TME by depleting L-arginine [44], while TGM2 plays a supporting role in M2 polarization by facilitating the extracellular matrix remodeling and promoting cell adhesion, thereby further enhancing tumor progression [45]. This evidence concerns the gene TGM2 and neoplasm.