S1PR3, which encodes for the sphingosine 1-phosphate receptor 3, and LAMA2, which encodes for the BTB junctional protein laminin subunit alpha 2, both known biomarkers of a permeable BTB [31], were overexpressed in adult GBM relative to normal brain tissue, while adult LGG showed underexpression of LAMA2 and a lower degree of S1PR3 overexpression relative to adult GBM (Table 3, Figure 3B). This evidence concerns the gene S1PR3 and glioblastoma.