In conclusion, while we are unable to make wide claims about the direct applicability of our studies to help in the management of mCRPC, we did provide some solid evidence for the role of the TLK1>MK5 axis in this progression, corroborated by a correlative PCa-TMA analysis of patients who presented (or not) lymph node involvement more frequently when the pMK5 stain was strong and cytoplasmic. This evidence concerns the gene TLK1 and posterior cortical atrophy.