ERBB2 and glioblastoma: Co expressions with low HER2 intensity there was a statistically significant association on increase of patient overall survival. HER2 positivity was found to be an independent prognostic marker in multivariate analysis. Furthermore, expression of HER2 positivity with cytoplasmic staining was also associated with significantly increase of overall survival in patients with glioblastoma (p = 0.022).