Collectively, the increases in AMP-related signaling, the NHE3 and RAAS inhibition, oxidative stress reduction, the increases in LDL receptor recycling, as well as the activation in cAMP/PKA, PI3K/AKT, and NO-cGMP-PKG pathways achieved by SGLT2i, PCSK9i, GLP1RA, sGCa, and a proper low GI diet provide a set of preventive and therapeutic strategies in particularly vulnerable patients such as those with cancer and CKM, consequently reducing MACE events and improving OS [210]. The gene discussed is AKT1; the disease is cancer.