We further analyzed the expression of ALDH1A3 in other types of cancer in TCGA and found that the expression of ALDH1A3 in cancer tissue of PRAD patients was the highest, indicating that the high expression of ALDH1A3 may play an important role in the occurrence, progression, or malignant transformation of PRAD, and it may be a key regulatory gene in prostate cancer (Figure 3F). This evidence concerns the gene ALDH1A3 and Familial prostate cancer.