These findings on a member of the PGRMC family conducted using a mouse model of endometrial cancer advance our prior studies demonstrating that the knockdown of PGRMC1 in a human endometrial xenograft tumor attenuated tumor development, growth, and progression in vivo [31], a finding also supported by ovarian and breast cancer xenograft studies [30,32]. This evidence concerns the gene PGRMC1 and neoplasm.