However, whereas all Ptend/d mice had to be euthanized prior to the end of the study at nine months, 100% of Ptend/d; Pgrmc2d/d mice survived to nine months of age, suggesting that the ablation of Pgrmc2 attenuated the progression of endometrial cancer (Figure 4B). This evidence concerns the gene PGRMC2 and endometrial cancer.