New renal tumor entities have been included in the long list of RCC [4], i.e., eosinophilic solid and cystic RCC (ESC RCC) (Figure 2), ELOC-mutated RCC, ALK-rearranged RCC, SMARCB1-deficient medullary RCC, TFEB-altered RCC, and FH-deficient RCC. This evidence concerns the gene TFEB and renal cell carcinoma.