Considering the complete NSCLC cohort (ADC and SCC), the univariable analysis revealed that a low CD39 expression in the tumor and its surrounding stroma cells was significantly associated with a worse prognosis (hazard ratio [HR]: 1.89; 95% confidence interval [CI]: [1.19, 2.99], p = 0.007 and HR: 2.20; 95% CI: [1.23, 3.94], p = 0.004, respectively). The gene discussed is ENTPD1; the disease is non-small cell lung carcinoma.