APOE and Apathy: Results of the adjusted Cox proportional-hazards model in the CN to MCI cohort (LRT: λ(11) = 86.26, P < 0.001) revealed a significant 2-fold increase in risk of conversion in APOE ε4 carriers who endorsed apathy compared to the reference group, APOE ε33 individuals without apathy (HR = 2.05, 95%CI = 1.04-4.02, P = 0.04; Figure 2(A)).