An increased risk of conversion for individuals APOE ε2 carriers with apathy (HR = 2.08, 95%CI = 0.62-7.03, P = 0.24), and attenuated risk for APOE ε2 carriers without apathy (HR = 0.57, 95%CI = 0.22-1.44, P = 0.23) was found to be non-significant. This evidence concerns the gene APOE and Apathy.