The APOE ε4 allele is the strongest known genetic risk factor for late-onset AD.9 Past research explored the convergence of neuropsychiatric symptoms in MCI, such as apathy, depression, and agitation, and APOE ε4 allele status; additive interactions between symptoms, including depression and apathy, and a positive APOE ε4 status were found to be associated with increased risk for developing dementia.10 However, the impact of apathy-APOE ε4 interactions, in isolation of other neuropsychiatric symptoms, on conversion from MCI to Alzheimer’s disease dementia (ADD) has not been examined. This evidence concerns the gene APOE and Alzheimer disease.