APOE and Apathy: Most notably, the main finding of greater risk of conversion with apathy and with antidepressant use was present across both APOE ε4 carriers (HR = 4.24, 95%CI = 2.38-7.53, P < 0.001) and non-carriers (HR = 2.82, 95%CI = 1.51-5.28, P = 0.001, Figure 5).