KDM1A and acute myeloid leukemia: A pivotal study by Lynch and coworkers provided evidence that pharmacological inhibitors of LSD1 promote the differentiation of myeloid leukemic cells through a mechanism independent of the inhibition of LSD1 enzymatic activity (histone demethylation) but dependent of the interaction between LSD1 and transcription factor GFI1, essential to maintain the differentiation block in AML [71].