IDH1 and acute myeloid leukemia: A large study involving the molecular characterization of 1023 older AML patients reported a frequency of 9.7% for IDH1MUT and 18.9% for IDH2MUT, including 1% for double-mutant IDH1/IDH2; IDH1MUT significantly co-occurred with DNMT3AMUT (42.4%), while IDH2MUT was associated with DNMT3AMUT (35.8%), NPM1MUT (31.1%), and SRFSF2MUT (38.3%) [9].