The findings of this case report suggest that Menin inhibitor monotherapy is not sufficient to obtain complete eradication of leukemic clones in NUP98 fusion-positive AML patients and that the cooperation between Menin inhibition and kinase inhibitors targeting either CDK6 or FLT3 strongly cooperate in NUP98-rearranged primary AML cells and in PDX models [133]. The gene discussed is MEN1; the disease is acute myeloid leukemia.