Particularly, in this context, the targeting of some molecules in non-APL AMLs, such as isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2), lysine-specific demethylase 1 (LSD1), and Menin, is associated with the induction of leukemic cell differentiation and significant therapeutic effects. Here, IDH2 is linked to acute promyelocytic leukemia.