In vitro studies in NPM1-mutant or MLL-rearranged leukemic cell lines or primary AML cells using the Menin inhibitor DS-1594b showed that the primary effect was the induction of cell differentiation and not of apoptosis; when the Menin inhibitor was associated with the BCL-2 inhibitor Venetoclax, the apoptotic effect was predominant [98]. This evidence concerns the gene NPM1 and acute myeloid leukemia.