The main chromosomal alterations identified in five HCC patients included a 1q gain in three out of five patients (H20, H18, H22), a gain of chromosome 7 (H18, H22), an 8q gain (H20, H18), 6p gain (H20, H18), 10p gain (H19, H18), and an 18q deletion (H19, H18). This evidence concerns the gene H19 and hepatocellular carcinoma.